In "The Perfect Castaway", while stuck on the island and given the choice of being blind or a midget, Quagmire muses that if he were blind, every woman he ever did would be Cheryl Tiegs.
In "Jerome Is the New Black", it is revealed that she was once in a serious relationship with Quagmire. When that relationship dissolved, the emptiness he felt led him to become the sex-crazed man his neighbors know him as today.
This romance with Quagmire will lead to her appearing in "Tiegs for Two" when Brian uses her to get even with Quagmire for ruining his chance at a relationship. Quagmire retaliates by taking Jillian out to the same restaurant for dinner but both girls leave when Brian and Quagmire start fighting.
- Family Guy Season 3 (Fisrt Appearence) (Poster)
- Family Guy Season 4 (Mentioned)
- Family guy Season 8 (Mentioned)
- Family Guy Season 9
- Family Guy Season 11
- Family Guy: The Quest For Stuff